Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
USERS' SCORE
Good
Based on 7 Reviews
8.4
Supplement Facts
Serving Size: 1 Nugget
Amount Per Serving
%DV
Vitamin B12 (as methylcobalamin)
5,000 mcg
208,333%
Top Medical Research Studies
9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Read More
9
We explored the intriguing case of a 56-year-old man diagnosed with Biermer's disease, also known as pernicious anemia, an autoimmune condition that leads to a lack of intrinsic factor and, consequently, vitamin B12 malabsorption. This patient presented with unusual symptoms: not just digestive concerns like melena, but also notable neurological effects such as memory issues and gait disturbances.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
Read More
8
We investigated the potential of vitamin B12 as a treatment for rheumatoid arthritis, particularly focusing on its ability to target an enzyme called peptidylarginine deiminase isoform 4 (PADI-4). PADI-4 plays a crucial role in a process called citrullination, which is often disrupted in autoimmune conditions like rheumatoid arthritis.
Our findings revealed that vitamin B12 effectively inhibits PADI-4, showing a preference for this enzyme over another similar one, PADI-2. This inhibition corresponds to a decrease in overall cellular citrullination, including the citrullination of histone H3, which is also mediated by PADI-4.
Additionally, we observed that hydroxocobalamin, a special form of vitamin B12, significantly reduced the severity of collagen type II antibody-induced arthritis in mice. It also lowered the expression of key inflammatory factors and cytokines associated with rheumatoid arthritis, such as IL-17A, TNFα, and IL-6.
These promising results suggest that vitamin B12 might be an effective therapeutic avenue for managing rheumatoid arthritis, warranting further investigation in future studies.
Our findings revealed that vitamin B12 effectively inhibits PADI-4, showing a preference for this enzyme over another similar one, PADI-2. This inhibition corresponds to a decrease in overall cellular citrullination, including the citrullination of histone H3, which is also mediated by PADI-4.
Additionally, we observed that hydroxocobalamin, a special form of vitamin B12, significantly reduced the severity of collagen type II antibody-induced arthritis in mice. It also lowered the expression of key inflammatory factors and cytokines associated with rheumatoid arthritis, such as IL-17A, TNFα, and IL-6.
These promising results suggest that vitamin B12 might be an effective therapeutic avenue for managing rheumatoid arthritis, warranting further investigation in future studies.
Read More
Most Useful Reviews
10
Highly effective B12
3 people found this helpful
Only thing that actually works. I had really low B12 levels (around 190) and had been taking other 1000mg cyanocobalamin tablets before breakfast daily for months. Despite this, my low levels persisted, so my doctor prescribed me 1000mg cyanocobalamin injections weekly for two months. However, my levels remained unchanged. Desperate, I decided to try these tablets, and they are genuinely the only thing that has worked for me. They keep my B12 levels high and taste great! I highly recommend these to anyone - nothing else works as effectively, even compared to injections!
Read More
9
Regulated nervous system
2 people found this helpful
I’ve been a raw vegan and experienced a severe B12 deficiency, leading me to order SOLGAR's B12 multiple times. This product has significantly helped to address my nerve issues as well as eliminating my constant fatigue. I now keep a bottle at home as essential backup.
Read More
9
Nerve issues resolved
2 people found this helpful
Superb product for vitamin B12 deficiency. This product has been exceptionally effective for me. As a raw vegan, I had been lacking B12 for several years without any supplements, which led to severe nerve system problems. Since I started using Methylcobalamin (B12) 5000 mcg/60 nuggets for several months now, all those issues have slowly vanished, and I feel much better. I ordered the B12 bottle on August 21, 2017, and it arrived in Europe by August 30. Quite fast, just within eight days! - D. Gelo, Croatia.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
- All Researches
9.5
Vitamin B12 supplementation benefits autoimmune patients
We explored the impact of vitamin B12 on patients with autoimmune disorders, particularly those experiencing symptoms often attributed to their underlying conditions. The study presented three cases of individuals with neuropathic pain, depression, fatigue, and muscle weakness, who had their symptoms initially misattributed to rheumatic diseases.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
Read More
9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Read More
9
We examined a fascinating case of a 54-year-old man experiencing the rare overlap of Guillain-Barré Syndrome (GBS) and autoimmune gastritis. After a thorough medical evaluation, which included MRI and biopsy, he was diagnosed with both GBS and a vitamin B12 deficiency linked to atrophic gastritis.
Treatment with intravenous immunoglobulin and methylcobalamin (vitamin B12) led to substantial improvement in his symptoms. This case highlights the importance of recognizing potential nutrient deficiencies, especially those impacting autoimmune disorders like GBS and autoimmune gastritis.
Treatment with intravenous immunoglobulin and methylcobalamin (vitamin B12) led to substantial improvement in his symptoms. This case highlights the importance of recognizing potential nutrient deficiencies, especially those impacting autoimmune disorders like GBS and autoimmune gastritis.
Read More
9
We explored the intriguing case of a 56-year-old man diagnosed with Biermer's disease, also known as pernicious anemia, an autoimmune condition that leads to a lack of intrinsic factor and, consequently, vitamin B12 malabsorption. This patient presented with unusual symptoms: not just digestive concerns like melena, but also notable neurological effects such as memory issues and gait disturbances.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
Read More
8
Vitamin B predicts GBS prognosis
We examined the levels of vitamin B and creatine kinase (CK-NAC) in 50 patients with Guillain-Barré Syndrome (GBS). Through clinical assessments, we compared the patients' functional abilities and found that a deficiency in vitamin B was linked to greater disease severity and respiratory complications.
However, while vitamin B levels seemed to offer insight into GBS prognosis, elevated CK-NAC levels did not show a significant correlation with disease severity. This points towards the importance of monitoring vitamin B as a potential prognostic tool in managing GBS.
However, while vitamin B levels seemed to offer insight into GBS prognosis, elevated CK-NAC levels did not show a significant correlation with disease severity. This points towards the importance of monitoring vitamin B as a potential prognostic tool in managing GBS.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Highly effective B12
3 people found this helpful
Only thing that actually works. I had really low B12 levels (around 190) and had been taking other 1000mg cyanocobalamin tablets before breakfast daily for months. Despite this, my low levels persisted, so my doctor prescribed me 1000mg cyanocobalamin injections weekly for two months. However, my levels remained unchanged. Desperate, I decided to try these tablets, and they are genuinely the only thing that has worked for me. They keep my B12 levels high and taste great! I highly recommend these to anyone - nothing else works as effectively, even compared to injections!
Read More
9
Regulated nervous system
2 people found this helpful
I’ve been a raw vegan and experienced a severe B12 deficiency, leading me to order SOLGAR's B12 multiple times. This product has significantly helped to address my nerve issues as well as eliminating my constant fatigue. I now keep a bottle at home as essential backup.
Read More
9
Nerve issues resolved
2 people found this helpful
Superb product for vitamin B12 deficiency. This product has been exceptionally effective for me. As a raw vegan, I had been lacking B12 for several years without any supplements, which led to severe nerve system problems. Since I started using Methylcobalamin (B12) 5000 mcg/60 nuggets for several months now, all those issues have slowly vanished, and I feel much better. I ordered the B12 bottle on August 21, 2017, and it arrived in Europe by August 30. Quite fast, just within eight days! - D. Gelo, Croatia.
Read More
9
Quick delivery
최고의 제품! The product was arranged perfectly and packed well, and I can definitely feel the effect! I will order more! It was delivered quickly.
Read More
7.5
Effective relief
10 people found this helpful
While I use 5000 micrograms of B12 by cutting it in half, I found it effective for my emotional panic disorder. Whenever I feel nervous, I place a half dose under my tongue, and the relief is almost immediate. I hope my experience assists others dealing with similar symptoms in reclaiming their lives!
Read More
Frequently Asked Questions
9
Nerve issues resolved
2 people found this helpful
Superb product for vitamin B12 deficiency. This product has been exceptionally effective for me. As a raw vegan, I had been lacking B12 for several years without any supplements, which led to severe nerve system problems. Since I started using Methylcobalamin (B12) 5000 mcg/60 nuggets for several months now, all those issues have slowly vanished, and I feel much better. I ordered the B12 bottle on August 21, 2017, and it arrived in Europe by August 30. Quite fast, just within eight days! - D. Gelo, Croatia.
7.5
Improved health
6 people found this helpful
As a vegetarian for a decade, I became concerned about my B12 levels. I took two pills weekly, aiming to boost my vitamin level according to my analysis. Consequently, my health has improved, energy has surged, and my B12 levels are now normal.
7.5
Effective relief
10 people found this helpful
While I use 5000 micrograms of B12 by cutting it in half, I found it effective for my emotional panic disorder. Whenever I feel nervous, I place a half dose under my tongue, and the relief is almost immediate. I hope my experience assists others dealing with similar symptoms in reclaiming their lives!
9
Regulated nervous system
2 people found this helpful
I’ve been a raw vegan and experienced a severe B12 deficiency, leading me to order SOLGAR's B12 multiple times. This product has significantly helped to address my nerve issues as well as eliminating my constant fatigue. I now keep a bottle at home as essential backup.
10
Highly effective B12
3 people found this helpful
Only thing that actually works. I had really low B12 levels (around 190) and had been taking other 1000mg cyanocobalamin tablets before breakfast daily for months. Despite this, my low levels persisted, so my doctor prescribed me 1000mg cyanocobalamin injections weekly for two months. However, my levels remained unchanged. Desperate, I decided to try these tablets, and they are genuinely the only thing that has worked for me. They keep my B12 levels high and taste great! I highly recommend these to anyone - nothing else works as effectively, even compared to injections!
8
Vitamin B predicts GBS prognosis
We examined the levels of vitamin B and creatine kinase (CK-NAC) in 50 patients with Guillain-Barré Syndrome (GBS). Through clinical assessments, we compared the patients' functional abilities and found that a deficiency in vitamin B was linked to greater disease severity and respiratory complications.
However, while vitamin B levels seemed to offer insight into GBS prognosis, elevated CK-NAC levels did not show a significant correlation with disease severity. This points towards the importance of monitoring vitamin B as a potential prognostic tool in managing GBS.
However, while vitamin B levels seemed to offer insight into GBS prognosis, elevated CK-NAC levels did not show a significant correlation with disease severity. This points towards the importance of monitoring vitamin B as a potential prognostic tool in managing GBS.
7
We explored a fascinating case of a 40-year-old woman suffering from long-standing, unclear symptoms, initially misdiagnosed with various conditions. After years of monitoring, her critically low vitamin B12 levels were finally recognized, revealing pernicious anemia as the root cause.
Thanks to treatment with B12 injections, we observed significant improvement in her neurological symptoms. This case illustrates the need for thorough evaluations in patients with non-specific symptoms, as addressing vitamin B12 deficiency can lead to meaningful improvements—even when classic signs are absent.
Thanks to treatment with B12 injections, we observed significant improvement in her neurological symptoms. This case illustrates the need for thorough evaluations in patients with non-specific symptoms, as addressing vitamin B12 deficiency can lead to meaningful improvements—even when classic signs are absent.
9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
7
We explored the clinical characteristics of Chinese patients with autoimmune gastritis (AIG), focusing on how dietary and lifestyle factors influence its occurrence.
In a comprehensive case-control study involving 479 participants, we discovered that a diet rich in vitamin B12 may help protect against AIG. Interestingly, factors like cooking oil usage and autoimmune thyroid disease increased AIG risk.
Our findings suggest that what we eat and our lifestyle choices can significantly impact the development and prognosis of autoimmune gastritis.
In a comprehensive case-control study involving 479 participants, we discovered that a diet rich in vitamin B12 may help protect against AIG. Interestingly, factors like cooking oil usage and autoimmune thyroid disease increased AIG risk.
Our findings suggest that what we eat and our lifestyle choices can significantly impact the development and prognosis of autoimmune gastritis.
8
We investigated the potential of vitamin B12 as a treatment for rheumatoid arthritis, particularly focusing on its ability to target an enzyme called peptidylarginine deiminase isoform 4 (PADI-4). PADI-4 plays a crucial role in a process called citrullination, which is often disrupted in autoimmune conditions like rheumatoid arthritis.
Our findings revealed that vitamin B12 effectively inhibits PADI-4, showing a preference for this enzyme over another similar one, PADI-2. This inhibition corresponds to a decrease in overall cellular citrullination, including the citrullination of histone H3, which is also mediated by PADI-4.
Additionally, we observed that hydroxocobalamin, a special form of vitamin B12, significantly reduced the severity of collagen type II antibody-induced arthritis in mice. It also lowered the expression of key inflammatory factors and cytokines associated with rheumatoid arthritis, such as IL-17A, TNFα, and IL-6.
These promising results suggest that vitamin B12 might be an effective therapeutic avenue for managing rheumatoid arthritis, warranting further investigation in future studies.
Our findings revealed that vitamin B12 effectively inhibits PADI-4, showing a preference for this enzyme over another similar one, PADI-2. This inhibition corresponds to a decrease in overall cellular citrullination, including the citrullination of histone H3, which is also mediated by PADI-4.
Additionally, we observed that hydroxocobalamin, a special form of vitamin B12, significantly reduced the severity of collagen type II antibody-induced arthritis in mice. It also lowered the expression of key inflammatory factors and cytokines associated with rheumatoid arthritis, such as IL-17A, TNFα, and IL-6.
These promising results suggest that vitamin B12 might be an effective therapeutic avenue for managing rheumatoid arthritis, warranting further investigation in future studies.
References
- Jatav VS, Sardana V, Bhushan B, Maheshwari D, Garg S, et al. Correlation of Serum Vitamin B and Muscle Enzyme (CK-NAC) Level with Severity of Guillain-Barre Syndrome and Its Prediction in Respiratory Failure. J Assoc Physicians India. 2025;73:48. doi:10.59556/japi.73.0892
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. doi:10.1186/s13256-025-05149-7
- Ma XY, Hao Y, Xie YH, Cao Q, Sun DF, et al. Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case-Control Study in China. J Gastroenterol Hepatol. 2025. doi:10.1111/jgh.16912
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Xiang H, Cai M. Coexistence of Guillain-Barré Syndrome and Subacute Combined Degeneration of the Spinal Cord Due to Autoimmune Gastritis: A Case Report and Literature Review. Cureus. 2024;16:e63084. doi:10.7759/cureus.63084
- Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, et al. Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Sci Transl Med. 2024;16:eadl3758. doi:10.1126/scitranslmed.adl3758
- Subtil J, Carvalho R, Rebelo AF, Subtil P. Autoimmune Polyglandular Syndrome Type 3: A Case Report. Cureus. 2024;16:e76152. doi:10.7759/cureus.76152
- Mansour M, Shamasnah A, Alsaadi D, Abu Saif S, Krama A. Evans syndrome as a presentation in systemic lupus erythematous, coexisting with Hashimoto's thyroiditis and pernicious anemia: a case report. J Med Case Rep. 2024;18:643. doi:10.1186/s13256-024-05002-3
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. doi:10.1007/s10067-024-07285-9
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. doi:10.1186/s12887-024-05262-4
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. doi:10.7759/cureus.58601
- Fernandez I, Touzot F. Looking for ALPS: The value of a combined assessment of biochemical markers. Pediatr Allergy Immunol. 2024;35:e14135. doi:10.1111/pai.14135
- Yamada H, Toko M, Nakamori M, Ueno H, Aoki S, et al. Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging. J Neurovirol. 2024;30:197. doi:10.1007/s13365-024-01203-0
- Yang CW, Hsu HY, Lee YZ, Lee SJ. Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice. Biochem Biophys Res Commun. 2024;704:149668. doi:10.1016/j.bbrc.2024.149668
- Dułak NA, Rytlewska M, Jaskólska M, Chmielewski M. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review. Rheumatol Int. 2024;44:737. doi:10.1007/s00296-024-05539-y
